Dr. Rahul Haware

Assistant Professor of Pharmaceutical Sciences

Bachelor of Pharmacy, Pharmaceutics, University of Pune, India

Master of Pharmacy, Pharmaceutics, University of Pune, India

MS, Molecular Biology, University of Heidelberg, Germany / University of Skövde, Sweden

PhD, Pharmaceutics, University of Tromsø, Norway

haware@campbell.edu

910-893-1802

Location: Maddox Hall, Room 214


Research Interest:
Dr. Haware's main research focus is on the emerging field of ‘Pharmaceutical Material Science’ to investigate the impact of the physico-mechanical properties of crystalline and amorphous materials on their final dosage form design. These properties include: particle size, shape, surface area, crystal structure, lattice energy, crystal forms (i.e. polymorphs and hydrates), relative crystallinity (and amorphous content), hygroscopicity and solubility. These properties affect powder flow, mixing, compaction and physical stability. Ultimately, they determine the final dosage form performance. The focus of his research is to use advanced analytical techniques like: powder and single crystal X-ray diffraction; differential scanning calorimetry; thermal gravimetric analysis; important modules in Material Studio®; and compaction simulator. Finally, he is interested to evaluate and model the generated information from these sophisticated techniques with the help of multivariate analysis techniques to develop predictive models within the subjected design space.


Peer-Reviewed International Publications:

  • S. G. Uppaluri, S. K. Bompelliwar, P. R. Johnson, M. R. Gupta, W. C. Stagner, R. V. Haware, Evaluation of The Moisture Prediction Capability of Near Infrared and Attenuated Total Reflectance Fourier Transform Infrared Spectroscopy Using Superdisintegrants as Model Compounds, (2014), submitted to J. Pharm. Sci.
  • R. K. Tekade, S.R. Youngren-Ortiz, H. Yang, R. V. Haware, M.B.Chougule, Designing Hybrid Onconase Nanocarriers for Mesothelioma Therapy: A Taguchi Orthogonal Array and Multivariate Component Driven Analysis, (2014), accepted to Mol. Pharm.

  • R. V. Haware, R. Shivagari, P. Johnson, S. Staton, W. C. Stagner, M. R. Gupta, Application of multivariate methods to evaluate functionality of bovine-and vegetable-derived magnesium stearate, J. Pharm. Sci., 103 (2014), 1466-1477.

  • D. Hu, R. V. Haware, M. L. Hamad, K. R. Morris, Characterization of physical and mechanical properties of freeze-dried grape powder for patient delivery system development, Pharmaceutical Development and Technology, 18 (2013), 146-155
  • R. V. Haware, Brian Nimi, Paul Kim, Lauren Ruffino, Catherine Fadrowsky, Michael Doyle, Stephan X.M. Boerrigter, Alberto Cutino, Ken Morris, Anisotropic crystal deformation measurements determined using powder X-ray diffraction and a new in situ compression stage, International Journal of Pharmaceutics, 418 (2011), 199-206
  • R. V. Haware, Patrick Wright, Ken Morris, Mazen Hamad, Application of data fusion technique for quantification and prediction of powder blend compositions, Journal of Pharmaceutical and  Biomedical Analysis, 56 (2011), 944-949
  • R. V. Haware, I. Tho, A. Bauer-Brandl, Suitability of “in-die” elastic recovery descriptors for rational tablet formulation development, Powder Technology, 202 (2010), 71-77
  • R. V. Haware, I. Tho, A. Bauer-Brandl, Comparative evaluation of the powder and compression properties of various grades and brands of microcrystalline celluloses by multivariate analysis, Pharmaceutical Development and Technology,15 (2010), 394-404
  • R. V. Haware, I. Tho, A. Bauer-Brandl, Multivariate analysis of relationships between material properties, process parameters and tablet tensile strength of α-lactose monohydrates, European Journal of Pharmaceutics and Biopharmaceutics, 73 (2009) 424-431
  • R. V. Haware, I. Tho, A. Bauer-Brandl, Application of multivariate methods to compression behavior evaluation of directly compressible materials, European Journal of Pharmaceutics and Biopharmaceutics, 72 (2009) 148-155
  • R. V. Haware, P. D. Chaudhari, S. R. Parakh, A. Bauer-Brandl, Development of a melting tablet containing promethazine HCl against motion sickness, AAPS PharmSciTech, 9 (2008) 1006-1015


Oral Presentations at International Meetings:

  • DM2 Approach for Evaluation and Prediction of the Powder Compression Properties, Compaction Simulation Forum, Philadelphia, USA (2014)
  • Crystal Morphology and Strength, Industrial Advisory Board Meeting, Rutgers University, Piscataway, New-Jersey, USA (2010)
  • Quantitative Relationship between Material Properties, Process Parameters and Tablet Tensile Strength for α-Lactose Monohydrates by Multivariate Analysis’, The 2nd  Pharmaceutical Sciences Fair and Exhibition (PharmSci Fair), Nice, France (2009)
  • Quantitative Relationship between Material Properties, Process Parameters and Tablet Tensile Strength for α-Lactose Monohydrates by Multivariate Analysis’, Pre-Satellite Meeting of the 2nd Pharmaceutical Sciences Fair and Exhibition, Nice, France (2009)
  • An Application of Heckel Equation and Multivariate Methods for the Evaluation of Compression Behavior of Powder Mixtures, 6th World Meeting on Pharmaceutics, Biopharmaceutics and Pharmaceutical Technology, Barcelona, Spain (2008)
  • Application of Multivariate Methods for Compression Behavior Evaluation of Powder Blends, The 2nd Midnight Sun Meeting on Drug Transport and Delivery, University of Tromsø, Tromsø, Norway (2008)


Poster Presentations at International Meetings:

  • Distinction of Powder and Compression Properties of Various Grades and Brands of Microcrystalline Celluloses by Heckel Equation and Multivariate Methods, Compaction Simulation Forum, Cambridge University, Cambridge, UK (2013)
  • Crystal Morphology and Strength, Industrial Advisory Board Meeting, Rutgers University, Piscataway, New-Jersey, USA (2010)
  • Distinction of Powder and Compression Properties of Various Grades and Brands of Microcrystalline Celluloses by Heckel Equation and Multivariate Methods, The 2nd Midnight Sun Meeting on Drug Transport and Delivery, University of Tromsø, Tromsø, Norway (2008)
  • Development of Rapidly Disintegrating Tablets Containing Promethazine Hydrochloride Against Motion Sickness, Pharmaceutical Science World Conference, Amsterdam, Netherlands (2007)
  • A New Tablet Press Simulator Device for Extremely Accurate Measurement of Time-Resolved Force and Displacement Based on an Electromechanical Press, Pharmaceutical Science World Conference, Amsterdam, Netherlands (2007)


Abstracts Presented:

  • Physico-Chemical Characterization of Binary Mixture of Microcrystalline Cellulose and α – Lactose Monohydrate Exposed at Different Storage Conditions, International Pharmaceutical excipient Council-Excipient Fest Americans, Raleigh, NC, USA (2014)
  • Effects of Storage Conditions on the Physicochemical Properties of MicroceLac®100, International Pharmaceutical excipient Council-Excipient Fest Americans, Raleigh, NC, USA (2014)
  • Application of Multivariate Methods to Evaluate the Functionality of Bovine- and Vegetable-Derived Magnesium Stearate, International Pharmaceutical excipient Council-Excipient Fest Americans, Raleigh, NC, USA (2014)

Abstracts accepted for AAPS

  • Application of Multivariate Methods to Evaluate Magnesium Stearate Molecular and Macroscopic Properties Impact on Lubrication Efficiency, accepted for The 2014 American Association of Pharmaceutical Sciences Annual Meeting, San Diego
  • Effect of Storage Conditions on Physico-mechanical Properties of Co-processed Excipients: MicroceLac® 100, accepted for The 2014 American Association of Pharmaceutical Sciences Annual Meeting, San Diego
  • Evaluation of the Disintegration Properties of Crosslinked Crosscarmellose Sodium and Sodium Starch Glycolate as Superdisintegrants, accepted for The 2014 American Association of Pharmaceutical Sciences Annual Meeting, San Diego
  • A Case Study of Effect of Binder Type on Dry Granulation and Tablet Compression Properties of a Model Formulation, accepted for The 2014 American Association of Pharmaceutical Sciences Annual Meeting, San Diego
  • Influence of the Physicomechanical Properties of Starches on their Tabletability, accepted for The 2014 American Association of Pharmaceutical Sciences Annual Meeting, SanDiego

Professional Memberships:

  • American Association of Pharmaceutical Scientist
  • International Pharmaceutical Excipient Council-Americans

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