Courses

MS in Pharmaceutical Sciences

Courses

PHSC 504 – Advanced Research in Pharmaceutical Sciences
Credit: Variable (Maximum 3 Hours)
This research course is intended for the advanced student. It continues the basic science research experience. This course is co-listed as PHAR 504.

PHSC 508 – Drug Development and Pharmaceutical Regulations
Credit: 2 Hours
This course provides basics in worldwide drug regulations, facilities and process qualification, and in the processes involved indrug discovery and development.  Students will learn how specific activities fit into the overall scheme of drug development, and evaluate the impact of each activity on the overall progression of a new drug candidate. The principles of good manufacturing practices (cGMP), quality control, and quality assurance are introduced. The basics of regulatory compliance, the global nature of regulations, and the importance of validation in the Pharmaceutical and Biotechnology Industries are presented. Federal regulations and documentation requirements are discussed.

PHSC 510 – Pharmacokinetics
Credit: 2 Hours
This course provides the student with an understanding of basic, clinically applicable pharmacokinetic formulas and the assumptions that are involved with their use in therapeutic drug monitoring. This course is co-listed as PHAR 410. 

PHSC 512 – Fundamentals of Cellular Pharmacology
Credit: 4 Hours
This course is required for MSPS students, and introduces the basic principles of structure activity relationships and biochemical pharmacology with emphasis on cell biology, physicochemical properties of functional groups, metabolism, receptor theory and signal transduction. Prerequisites: Anatomy & Physiology and Biochemistry.

PHSC 514/515/515L – Industrial Pharmacy/Pre-Lab/Lab
Credit: 3/1 Hours
This survey course introduces student to the pre-formulation and manufacturing of pharmaceutical dosage forms. Students gain hands-on experience in the laboratory setting performing a variety of USP tests and unit operations. Prerequisites: Biochemistry with lab. Credit cannot be received for both PHSC 514/515 and PHSC 418/419.

PHSC 518/518L – General Toxicology
Credit: 3 Hours
This course is designed to give the student a broad appreciation of the field of Toxicology. The student is guided through the mechanisms by which toxicants enter the body and the biotransformation processes that result in the disease-producing entities. The various cellular mechanisms of toxicity and the major target organs affected by toxins will be treated in some detail. Didactic material may be augmented with both in vivo and in vitro experimental laboratories for assessing toxicity. Aspects of environmental, forensic, clinical toxicology and risk assessment will also be addressed in this course.  Prerequisites: PHAR 412 or PHSC 512.  This course is co-listed as PHAR 518.

PHSC 522 – Molecular Modeling
Credit: 2 Hours
This informal course trains students in the use of high performance computing systems to solve problems in biological modeling. Lecture topics include a review of high performance computing in molecular modeling, electron density calculations, 3D protein representation docking of molecules. We will use Silicon Graphics O2 and Cray T90 systems. Material is presented both in lectures and supervised lab sessions, during which students do interactive programming. The course is designed for students who are interested in viewing and taking a virtual walk through a complex molecule. This course is co-listed as PHAR 542.

PHSC 523 – Graduate Experimental Design & Biostatistics
Credit: 4 Hours
Statistical methods in health sciences: The course is intended to provide the student with basic knowledge of descriptive statistics, probability theory, hypothesis testing, and other selected statistical methods.  In addition, the course enables the student to utilize a statistical software program to apply their knowledge of the subject.

PHSC 526/526L – Protein Analysis & Bioassay/Laboratory
Credit: 4 Hours
The combined lecture and lab course covers advanced analysis of proteins from a theoretical standpoint and introduces the concept of bioassay. The analytical techniques covered are commonly used as part of the Quality Control for industrial production of proteins. Techniques covered include electrophoresis-based analyses, spectroscopic techniques, immunological assays, and chromatography. Bioassay topics will cover the use of both cells and whole organisms as the means of quantifying the biological activity of protein products. The course will combine lectures with hands-on laboratory exercises. Due to limited availability of certain advanced equipment, some exercises may be done as dry-labs and focus on analysis of instructor-provided data.

PHSC 528/529L – Advanced Pharmaceutical Analysis – Separation/Laboratory
Credit: 3/1 Hours
Emphasizes separation techniques used for the analysis of drugs, drug metabolites, toxic substances, and biological fluids and tissues. Theory and applications of liquid chromatography, sample preparation, method optimization, and process validation are discussed. Students learn the current state-of-the art procedures for the isolation, purification, derivatization, and characterization of complex chemical and biological samples.  Prerequisites: PHSC 410/411/411L or equivalent.

PHSC 530/531L – Advanced Pharmaceutical Analysis – Spectroscopy/Laboratory
Credit: 3/1 Hours
Applications of spectrophotometric methods of analysis (ultraviolet/visible, infrared, nuclear magnetic resonance, mass spectrometry, fluorescence, and atomic absorption/emission) to pharmaceutically important materials. It covers physical principles, theories, instrumentation, and interpretation of spectrometric data. Prerequisites: PHSC 410/411/411L or equivalent.

PHSC 534 – Masters of Science Seminar I
Credit: 1 Hour
This course involves scheduled meetings of students and faculty to review and discuss the literature in the various areas of pharmaceutical sciences.  The goal of this course is to develop students’ ability to critically evaluate scientific literature.

PHSC 536 – Masters of Science Seminar II
Credit: 1 Hour
In this course students will practice literature research and presentation by presenting a research paper in an area outside of their track.  The goal of this course is to develop students’ literature searching, writing skills, presentation skills and ability to critically evaluate primary scientific literature. Prerequisite: PHSC 534.

PHSC 538/538L – Bioprocessing I: Upstream Technologies/Lab
Credit: 4 Hours
This course provides an introduction to the theory and application of biotechnology procedures to the development of biopharmaceutical products. Students are provided with an overview of fermentation and cell culture principles, bioprocess design and validation, and pharmaceutical product generation. Prerequisites: PHSC 526/526L, Molecular Biology (completed or concurrent) and Microbiology.

PHSC 539/539L – Bioprocessing II: Downstream Operations/Lab
Credit: 4 Hours
This course continues the introduction to the theory and application of biotechnology procedures to the development of biopharmaceutical products begun in PHSC 538. Students are provided with an overview of protein purification, biopharmaceutical formulation, and stability of protein therapeutics. Prerequisite: PHSC 526/526L

PHSC 540 – Advanced Physical Pharmacy
Credit: 3 Hours
A comprehensive course in the physical and chemical properties of drugs and other pharmaceutical substances. This course will cover thermodynamics, solubility theory, interfacial phenomena, adsorption and absorption, micrometrics, complexation, viscoelasticity, advanced kinetics theory, and targeted drug delivery systems. Discussion involving issues related to the above topics will be supplemented with journal articles. Prerequisite: grade of C or better in PHSC 418/419/419L or PHSC 514/515/515L.

PHSC 542 – Advanced Topics in Industrial Pharmacy
Credit: 3 Hours
This is a project-oriented course in the design and manufacture of pharmaceutical dosage forms. This hands-on course places emphasis on the application of cGMPs in the preparation of dosage forms. Prerequisite: grade of C or better in PHSC 418/419/419L or PHSC 514/515/515L.

PHSC 543L – Advanced Industrial Pharmacy Lab
Credit: 1 Hour
The emphasis of this graduate-level Advanced IP Laboratory course is on the formulation, manufacture, and analysis of various pharmaceutical dosage forms (including sterile, liposomes, lyophilized, and nano-colloidal products) in a cGMP simulated environment equipped with the most advanced state-of-art manufacturing and analytical equipment. The laboratory requires students to apply knowledge gained from previous courses.  Prerequisite: PHSC 418/419/419L or PHSC 514/515/515L.

PHSC 558 – Essentials of Toxicology
Credit: 2 Hours
The General Toxicology course is designed to give the student a broad appreciation of the field of Toxicology. This includes the absorption, distribution, metabolism and elimination of toxicants from the body, as well as the mechanisms of specific toxicity to target organs. Significant treatment of the areas of Forensic, Environmental and Clinical toxicology are also undertaken. Prerequisites: PHAR 412 or PHSC 512.

PHSC 564 – Pharmacogenetics
Credit: 2 Hours
The basic principle of pharmacogenetics/pharmacogenomics and their relationship to current drug development are discussed.  This course is co-listed as PHAR 594 and CLNR 528.

PHSC 565 – Advanced Experimental Design
Credit: 2 Hours
This course illustrates the application of design of experiment as a tool in research and industry. Prerequisite: PHSC 324, CLNR 324, PHAR 523 or 528. This course is co-listed as PHAR 566.

PHSC 573 - Introduction to Multivariate Analysis (MVA)
Credit: 1 Hour
This course demonstrates the applications of advanced statistical tool, MVA, as data evaluation and prediction tool in pharmaceutical research and industries.  Prerequisites: PHSC 565.

PHSC 574 – Biopharmaceutics
Credit: 3 Hours
This course presents the biological and physiochemical factors of the body, drugs and dosage forms that influence drug availability, disposition, and pharmacological and toxicological responses. This course co-listed as PHAR 314 and PHSC 474.

PHSC 577 – Pharmacology & Medicinal Chemistry II
Credit: 4 Hours
Part of the series of PharmD Pharmacology/Medicinal Chemistry courses, PHSC 577 examines the pharmacology/medicinal chemistry of drugs that modulate neuromuscular transmission and the autonomic nervous system. The course will cover drugs used in the treatment of cardiovascular diseases such as hypertension, cardiac arrhythmias and congestive heart failure. Prerequisite: PHAR 412 or PHSC 512.  This course is co-listed as PHAR 417.

PHSC 578 - Good Regulatory (GXP) Practices
Credit: 2 Hours
This course will provide in-depth review of cGMP requirements for a bio-/pharmaceutical and other FDA regulates industries. Compliance to 21 CFR Parts 210 & 211 and other requirements is essential for these companies to survive in FDA regulated environment. Compliance is feasible only if employees are knowledgeable of these requirements and practice in their day-to-day activities

PHSC 581 – Pharmacology & Medicinal Chemistry III
Credit: 4 Hours
Part of the series of PharmD Pharmacology/Medicinal Chemistry courses, PHSC 581 examines the pharmacology/medicinal chemistry of hormone agonists, antagonists, and other drugs that modulate the endocrine system, drugs used to modulate autocoid activity including prostaglandins and histamine, and drugs used to treat mental disorders and CNS diseases.  Special emphasis will be placed on their mechanisms of action, structure activity relationships and major adverse effects. Prerequisite: PHAR 412 or PHSC 512 This course is co-listed as PHAR 421.

PHSC 582 – Botanical Medical Seminar
Credit: 1 hour
This course is an investigation of the use of herbal preparations in the rational application in pharmacy. The course is intended to provide the student with a basic knowledge of botanical and herbal preparations. This information will be given in a seminar style where students will be required to read and prepare to discuss articles on these agents.  This course is co-listed as PHAR 582.

PHSC 583 –Pharmacology & Medicinal Chemistry IV
Credit: 3 Hours
Part of the series of PharmD Pharmacology/Medicinal Chemistry courses, PHSC 583 examines the pharmacology/medicinal chemistry of agents used to treat infectious and neoplastic diseases. Immunomodulating agents in the treatment of organ transplantation are also discussed. Included are the broad range of antibacterial agents, antifungal agents, antiparasitic agents, antiviral agents, antineoplastic agents, vaccines and immunomodulatory agents.  Prerequisite: PHAR 412 or PHSC 512.  This course is co-listed as PHAR 423

PHSC 590/590L – Advanced Pharmacology & Toxicology/Lab
Credit: 3 Hours
This course is required for the pharmacology track of the MSPS degree, and provides details on the theory and methodologies of modern pharmacology and toxicology. Class will consist of lecture and lab time to provide the student hands-on experience in a variety of techniques and data analysis. Topics covered will include radioligand binding analysis, in vitro and in vivo functional assays, and toxicological screening methods. Prerequisites: Grade of B or better in PHSC 512.

PHSC 592 – Advanced Cellular & Molecular Pharmacology
Credit: 3 Hours
This course involves a detailed treatment of the various receptor/signal transduction systems found in mammalian systems from the perspective of developing them as therapeutic targets. Aspects of ion channel pharmacology, cyclic AMP and inositol phosphate signaling in pathological conditions will be discussed. The pharmacological control of tyrosine kinase signaling pathways and cell cycle regulation in the therapy of neoplastic disease will be addressed as well. The regulation of gene expression by inhibition of transcription or gene knockout/replacement strategies will also be discussed. The coursework for the class will entail lectures and systematic evaluation of the primary literature in the topics being covered. Prerequisite: Grade of B or better in PHSC 512.      

PHSC 610 – Research Proposal
Credit: 2 Hours
This course represents the development of the proposal for a research project.  Students will provide a written and oral presentation of their research proposal at the end of PHSC 610 for the major determinant of their grade. Prerequisites: MSPS students who have completed at least 6 credits of track-specific graduate coursework (not including core courses).

PHSC 620 – Research Project
Credit: 4 Hours
The research project is intended to provide students with a practical, hands-on application of previously obtained knowledge from the didactic setting and will be conducted under the guidance of a major advisor and a Research Project Committee of at least two other faculty members. Project proposals developed in PHSC 610 must be pre-approved and guided by the Committee. Students will provide a written and oral presentation of their research project as the major determinant of their grade for PHSC 620.  Prerequisites: MSPS students in good academic standing (not on academic probation) who have earned a grade of B or better and approval of their proposed project in PHSC 610.