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Pharmaceutical Sciences
Pharmaceutical Sciences |
Pharmaceutical Sciences Course Listing
Professors: Dr. Diliberto (Chair),
Dr. Greenwood (Associate Chair), Dr. Holmes (Associate Dean for
Academic Affairs)
Associate Professors: Dr. Al-Achi,
Dr. Junker, Dr. Shin
Research Associate Professor: Dr.
Chazotte
Assistant Professors:
Dr. Abraham, Dr. Bloom, Dr. Breivogel, Dr. Fetterman, Dr. Garrett, Dr.
Hamrick, Dr. Mosley, Dr. Nemecz
Instructors: Ms. Kelly,
Mr. Gallagher
Adjunct Faculty: Ms.
Brown, Dr. Campbell, Dr. Coffin, Dr. Gibson, Dr. Garcia, Dr. Green, Dr.
Jiang, Mr. Kiernan, Dr. Krishnamoorthy, Dr. G. Pande, Dr. P. Pande, Dr.
Parr, Dr. Spancake, Dr. Suryakusuma, Dr. Wagner, Dr. Waterhouse, Dr.
Wells, Dr. Wrenn, Dr. Yates
Major in
Pharmaceutical Sciences (CIP 51.2003)
The objective of this major is
to prepare students for careers in the biomedical sciences with
particular emphasis on pharmaceutical sciences. Graduates will be
prepared to enter research and technical positions in the health science
industries or to pursue postgraduate studies.
Candidates for the BS degree with a
major in the pharmaceutical sciences (BSPS) must satisfy all College of
Arts and Sciences requirements as set forth in the General College
Curriculum section of the university catalog. Prior to entering the
major, students must have completed a minimum of 64 semester hours of
college credit taken from the core liberal arts curriculum and must
include the following courses or their equivalents: Basic Biology, Human
Anatomy and Physiology, Microbiology and Immunology, General Chemistry
(2 semesters), Organic Chemistry (2 semesters), Calculus, and General
Physics (2 semesters).
In addition to the General Core
Curriculum (GCC) requirements as set by the university, pharmaceutical
sciences majors must complete the following didactic and laboratory
courses to earn a BS degree in this major: PHSC 210, PHSC 220/220L,
PHSC 323/325, PHSC 324, PHSC 326/327, PHSC 328, PHSC 334, PHSC 336, PHSC
338, PHSC 410/411, PHSC 418/419, PHSC 438/439, PHSC 442, and PHSC 451.
Following these courses, pharmaceutical sciences majors are required to
complete a semester-long internship, along with a final senior
internship presentation (PHSC 416 and PHSC 420). GCC courses and
pharmaceutical sciences courses total 134.5 credit hours.
North Carolina has one of the largest
concentrations of pharmaceutical and biotechnology industries in the
United States. It is also one of the most rapidly growing areas in the
state. Currently, there are hundreds of pharmaceutical research and
manufacturing sites in North Carolina. A majority of these
pharmaceutical and biotechnical companies are located in nearby Research
Triangle Park.
Additionally, several major research
universities and government agencies are nearby. Students may choose an
internship site based upon their future career goals including academic,
research, manufacturing, analytical, biotechnology, forensics,
formulation, or validation. In addition to hosting senior BSPS students
for their internships and summer employment, many of these sites also
provide opportunities for permanent positions upon graduation.
Pharmaceutical Sciences Course
Listing (PHSC 000)
210 Laboratory Safety (1)
An introduction to chemical, physical, and biological hazards associated
with laboratory work. Students are introduced to laboratory worker
regulations, methods for laboratory and personnel monitoring, and
personal protective equipment and clothing. Note: PHSC 210 is a
prerequisite (or corequisite) to all laboratory courses in
pharmaceutical sciences.
220/220L Quantitative Laboratory
Techniques (2)
An introductory laboratory
course concentrating on the basic terminology and mathematical skills
needed to perform routine laboratory procedures. Students learn the
theory and application of appropriate techniques involved in gravimetric
and volumetric analysis. Laboratory skills are honed through a series of
exercises that culminate in a comprehensive practical examination
designed to test the student’s ability to accurately formulate complex
biochemical solutions.
323/325 General Biochemistry/Lab
(3/1)
This introductory lecture and
laboratory course provides an overview of the synthesis and metabolism
of amino acids, carbohydrates, lipids, and nucleic acids; enzyme
kinetics; bioenergetics; and macromolecular structure and function.
Corequisite: PHSC 220/220L.
324 Experimental Design and
Biostatistics (4)
The application of statistical
analyses to the design, conduct, and interpretation of pharmaceutical
research, development, testing, and manufacturing is provided in this
comprehensive course. This course is co-listed as PHAR 528.
326/327 Molecular Biology/Lab (3/1)
Fundamental principles of
recombinant DNA technology are presented with an emphasis on
pharmaceutical applications where appropriate. Laboratory exercises
provide a basic understanding of the techniques involved in
biotechnology and to provide practical laboratory experience in the use
of these techniques. The lecture and laboratory courses are designed to
complement one another and work in tandem to give an overall view of
biotechnology. Prerequisite: PHSC 451.
328 Introduction to Pharmacology
(4)
The basic principles of
pharmacology and toxicology are covered through discussion of the
responses of biological systems to drugs and chemicals. The course also
considers the absorption, distribution, metabolism, and excretion of
xenobiotics and how these factors relate to drug action. Prerequisites:
Anatomy and Physiology and Organic Chemistry I.
334 and 336 Scientific Literature
Seminar I & II (1 and 1)
Students are introduced to
literature searching and critical analysis techniques in this series of
courses. The courses promote the formulation of critical thinking
approaches. Special emphasis is placed on communication techniques.
Students apply their knowledge and skill in the form of written and oral
presentations developed by researching the current pharmaceutical and
biomedical literature. Prerequisite: PHSC 451.
338 Product and Process Validation
(2)
The principles of current good
manufacturing practices (cGMP), process troubleshooting, quality
control, and quality assurance are introduced. Federal regulations and
documentation requirements are discussed throughout the course. The
course covers in detail the theory and practices by which pharmaceutical
and biotechnology processes are validated.
404 Research in Pharmaceutical
Sciences (1-3)
The purpose of this elective
course is to introduce pharmaceutical sciences students to methods of
basic science and/or clinical research. This involves application of the
scientific processes of hypothesis formation, literature evaluation,
experimental design, development of technical skills, data acquisition
and analysis, and formal presentation of results.
410/411 Analytical Instrumentation
(3/1)
A comprehensive introductory
course that provides students with an in-depth study of the theory and
operation of scientific instrumentation typically found in
pharmaceutical, chemical, and biotechnical research and analytical
facilities. Students gain hands-on experience with a variety of
spectroscopic and chromatographic instrumentation through structured
laboratory experiments and student-initiated research projects.
Prerequisites: PHSC 220/220L, PHSC 324, or permission of the
instructor.
414 Research Seminar (1)
Used in conjunction with
research courses PHSC 404 and 504, research seminar provides students
with an opportunity to present original research work to pharmaceutical
sciences faculty and students.
416 Senior Seminar (1)
Senior Seminar provides a
forum through which students chronicle their internship experiences.
Students present an overview of the companies in which they worked and
provide a synopsis of their roles in the organizations.
418/419 Industrial Pharmacy/Lab
(3/1)
This survey
course introduces students to the
pre-formulation and manufacturing of pharmaceutical dosage forms such as
tablets, capsules, sustained release preparations, ointments, and
suspensions. In the
laboratory portion of
the course, students gain hands-on experience performing a variety of USP tests and unit operations. Prerequisites: PHSC 220/220L, PHSC
323/325, and PHSC 410/411.
420 Senior Internship (12-14)
The internship provides
practical experience in the pharmaceutical, chemical, or biotechnology
industries. Students and participating industrial facilities are matched
to provide a comprehensive work experience. Note: Internships
completed during the summer will earn 12 credit hours rather
than 14.
438/ 439 Pharmaceutical Methodology
and Bioprocessing/Lab (3/1)
In this advanced analytical
techniques and instrumentation course, students are exposed to the
current state-of-the-art procedures for the isolation, purification,
derivatization, and characterization of complex chemical and biological
samples. These techniques are then applied to practical analytical
situations. Students are also provided with practical hands-on
experience in USP methodology and with a comprehensive overview of
bioprocessing. Prerequisite: PHSC 410/411.
442 Interpersonal Skills (2)
In this course, students will
learn about the various factors involved in developing good
interpersonal skills including: self-awareness, perception,
understanding individual differences, verbal and non-verbal
communication, goal setting, listening and feedback, teamwork,
leadership development, conflict resolution, motivation, negotiation,
and interviewing skills. The course will provide a forum for group
discussions and team exercises.
450/450L Spreadsheet/Data Analysis
(1-2)
This course introduces
students to advanced functions within commercial spreadsheet programs.
Emphasis is placed on the utilization of macros and embedding functions
as they apply to data analysis.
451 Scientific and Technical
Writing (1.5)
This required course is
presented to assist students in the enhancement of their skills in the
areas of scientific and technical writing.
452 Pharmaceutical Utilities
Systems (1-3)
This course gives students a
basic overall understanding of the utility systems used in
pharmaceutical manufacturing facilities. By using piping and
instrumentation diagrams (P&IDs) to teach these systems, students also
become familiar with one of the most commonly used types of engineering
documentation in the industry. This course also covers the basic
requirements for commissioning and validation of these systems.
462 and 466 Anatomy and Physiology
(4 and 4)
This two-course sequence
presents a comprehensive study of the structure and function of all
organ systems as well as basic biochemical and biophysical principles of
cellular and membrane function. Relevance to clinical states and drug
action is also presented in many areas. These courses are co-listed as PHAR 302 and 306. Prerequisite: Permission of instructor.
464 Biochemistry (4)
A comprehensive course in
biochemistry that discusses the metabolism of amino acids,
carbohydrates, lipids, and nucleic acids. Principles of enzyme kinetics
and regulation, bioenergetics, and macromolecular structure-function
relationships are presented. This course is co-listed as PHAR 304.
Prerequisite: Permission of instructor.
468 Clinical Biochemistry (3)
This course discusses the
principles of quantitative analysis utilized in common clinical
laboratory tests. An introduction to interpretation of abnormal clinical
laboratory values is presented. Quantitative aspects of nutrition are
presented, and regulatory effects of various hormones are described.
Diseases such as arteriosclerosis and diabetes are discussed. This
course is co-listed as PHAR 308. Prerequisite: Permission of instructor.
470 Immunology (4)
This course covers basic
immunology and the fundamental principles relating to the immune
response in normal and disease states. This course is co-listed as PHAR
310. Prerequisite: Permission of instructor
472 Medical Microbiology (3)
The basic concepts of medical
microbiology are presented. Information necessary to diagnose and manage
an infected patient are covered. Current, important bacteriologic,
virologic, mycotic, and parasitic pathogens and their related diseases
are discussed. Clinical presentations, principles of laboratory
diagnosis, and preventative measures are emphasized. This course is
co-listed as PHAR 312. Prerequisites: Immunology (PHAR 310/PHSC 470) and
permission of instructor.
474 Biopharmaceutics (3)
This course presents the
biological and physiochemical factors of the body, drugs and dosage
forms that influence drug availability, disposition, and pharmacological
and toxicological responses. This course is co-listed as PHAR 314.
Prerequisites: Permission of instructor, Anatomy and Physiology,
and Biochemistry.
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